Article
10q26 - The enigma in age-related macular degeneration.
Progress in retinal and eye research - 1 Sept 2023
Merle David A, Sen Merve, Armento Angela, Stanton Chloe M, Thee Eric F, Meester-Smoor Magda A, Kaiser Markus, Clark Simon J, Klaver Caroline C W, Keane Pearse A, Wright Alan F, Ehrmann Michael, Ueffing Marius
Abstract excerpt
Despite comprehensive research efforts over the last decades, the pathomechanisms of age-related macular degeneration (AMD) remain far from being understood. Large-scale genome wide association studies (GWAS) were able to provide a defined set of genetic aberrations which contribute to disease risk, with the strongest contributors mapping to distinct regions on chromosome 1 and 10. While the chromosome 1 locus...
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