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Article

Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?

Advances in experimental medicine and biology - 1 Jan 2016

Kortvely Elod, Ueffing Marius

Abstract excerpt

Age-related macular degeneration (AMD) is a sight-threatening disorder of the central retina. Being the leading cause of visual impairment in senior citizens, it represents a major public health issue in developed countries. Genetic studies of AMD identified two major susceptibility loci on chromosomes 1 and 10. The high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high...

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Source

Identifiers

PMID: 26427389
DOI: 10.1007/978-3-319-17121-0_4

Genes

ARMS2
HTRA1
PLEKHA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?PMID 26427389Read ↗

10q26 - The enigma in age-related macular degeneration.Semantic proximity Read ↗

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.Semantic proximity Read ↗

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.Semantic proximity Read ↗

Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.Semantic proximity Read ↗

Chromosome 10q26 locus and age-related macular degeneration: a progress update.Semantic proximity Read ↗

Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular DegenerationSemantic proximity Read ↗

Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.Semantic proximity Read ↗

Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.Semantic proximity Read ↗

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Characterization of the 10q26-orthologue in rhesus monkeys corroborates a functional connection between ARMS2 and HTRA1.Semantic proximity Read ↗

Transcriptome-wide association implicates <i>HTRA1-AS1</i> in age-related macular degeneration riskSemantic proximity Read ↗

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