A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.

doi:10.1073/pnas.0703933104

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Article

A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.

Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2007

Kanda Atsuhiro, Chen Wei, Othman Mohammad, Branham Kari E H, Brooks Matthew, Khanna Ritu, He Shirley, Lyons Robert, Abecasis Gonçalo R, Swaroop Anand

Abstract excerpt

Genetic variants at chromosomes 1q31-32 and 10q26 are strongly associated with susceptibility to age-related macular degeneration (AMD), a common blinding disease of the elderly. We demonstrate, by evaluating 45 tag SNPs spanning HTRA1, PLEKHA1, and predicted gene LOC387715/ARMS2, that rs10490924 SNP alone, or a variant in strong linkage disequilibrium, can explain the bulk of association between the 10q26...

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Identifiers

PMID: 17884985
DOI: 10.1073/pnas.0703933104
PMCID: PMC1987388

Genes

ARMS2
HTRA1
PLEKHA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.PMID 17884985Read ↗

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