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Article

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.

Molecular vision - 1 Jan 2017

Liao Sha-Mei, Zheng Wei, Zhu Jiang, Lewis Casey A, Delgado Omar, Crowley Maura A, Buchanan Natasha M, Jaffee Bruce D, Dryja Thaddeus P

Abstract excerpt

PURPOSE: A region within chromosome 10q26 has a set of single nucleotide polymorphisms (SNPs) that define a haplotype that confers high risk for age-related macular degeneration (AMD). We used a bioinformatics approach to search for genes in this region that may be responsible for risk for AMD by assessing levels of gene expression in individuals carrying different haplotypes and by searching for open chromatin...

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Source

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Identifiers

PMID: 28659708
PMCID: PMC5479693

Genes

HTRA1
ARMS2
PLEKHA1
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.PMID 28659708Read ↗

10q26 - The enigma in age-related macular degeneration.Semantic proximity Read ↗

Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.Semantic proximity Read ↗

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Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.Semantic proximity Read ↗

Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration.Semantic proximity Read ↗

Chromosome 10q26 locus and age-related macular degeneration: a progress update.Semantic proximity Read ↗

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