Article

Transcriptome-wide association implicates <i>HTRA1-AS1</i> in age-related macular degeneration risk

2025-12-07

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment and legal blindness that has significant genetic risk factors, including genetic variation within a locus on chromosome 10 encompassing several extensively studied protein-coding genes ( ARMS2, HTRA1 and PLEKHA1 ). Here, through transcriptome-wide association and fine-mapping approaches that integrate newly available high...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4def0b3d-466f-52f8-8067-deb58b44aa82
DOI: 10.64898/2025.12.05.25341732

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptome-wide association implicates <i>HTRA1-AS1</i> in age-related macular degeneration riskDOI 10.64898/2025.12.05.25341732Read

<i>HTRA1-AS1</i> , an <i>ARMS2</i> -region long non-coding RNA, is downregulated in retinas of age-related macular degeneration patientsSemantic proximity Read

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1.Semantic proximity Read

10q26 - The enigma in age-related macular degeneration.Semantic proximity Read

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration.Semantic proximity Read

Single-cell quantitative trait loci analyses identify expression changes in macular degeneration risk genesSemantic proximity Read

Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium.Semantic proximity Read

Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate pathogenic variants in age-related macular degenerationSemantic proximity Read

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.Semantic proximity Read

Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: <i>HTRA1</i> /lncRNA <i>BX842242.1</i> dominates, with no evidence for Complement Cascade involvementSemantic proximity Read

Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration.Semantic proximity Read

Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration.Semantic proximity Read

Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseasesSemantic proximity Read