Article
Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.
Investigative ophthalmology & visual science - 1 Apr 2010
Hadley Dexter, Orlin Anton, Brown Gary, Brucker Alexander J, Ho Allen C, Regillo Carl D, Donoso Larry A, Tian Lifeng, Kaderli Brian, Stambolian Dwight
Abstract excerpt
Purpose. To determine the relationship of six genetic variants (rs10490924, rs3750848, del443ins54, rs3793917, rs11200638, and rs932275) localized to the ARMS2-HTRA1 region of chromosome 10, region q26, as risk factors for age-related macular degeneration (AMD), to define the haplotype structure of these six loci, and to confirm their genetic association with the disease. Methods. Caucasian patients (n = 482)...