Article
Identification of circulatory neuro-related proteins in Parkinson's disease: an integrated genetic-proteomic-clinical study.
EBioMedicine - 1 Mar 2026
Zhou Hang, Wang Zihao, Tan Zixin, Deng Bin, Yang Wanlin, Huang Zifeng, Guo Xingfang, Li Jintao, Wang Xinhao, Yu Yinghua, Deng Chao, Zheng Wenhua, Zhang Xu, Chen Xi, Yue Jianhui, Yang Chengwu, Cui Xiaoying, Poplawska-Domaszewicz Karolina, Chaudhuri K Ray, Zhou Zhidong, Xiao Bin, Chan Ling-Ling, Foo Jia Nee, Tan Eng-King, Wang Qing
Abstract excerpt
BACKGROUND: Neuro-related proteins are promising biomarkers and therapeutic targets for Parkinson's disease (PD), yet their specific roles remain uncertain. METHODS: We conducted Mendelian randomisation by integrating protein quantitative trait loci with genome-wide association study data from 33,647 patients with PD and 449,056 controls for risk, 28,568 patients for age at onset (AAO), and 4093 patients for...
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