Article

Sex-biased Genetic Risk Loci and Causal Brain Proteins in Parkinson’s Disease

2026-06-25

Abstract excerpt

Parkinson’s disease (PD) exhibits pronounced sex differences, yet the underlying genetic and molecular mechanisms remain poorly understood. We performed the largest-to-date meta-analysis of sex-stratified genome-wide association studies of PD followed by brain proteogenomics-based causal inference analyses. We nominated 10 candidate proteins that appear important to sex-biased PD risk, of which 2 female-biased, GA...

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Literature Corpus work: 6e0c0e32-86ce-5c12-a1b0-0f39fcfffec0
DOI: 10.64898/2026.06.23.26356345

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