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Integrating plasma circulating protein-centered multi-omics to identify potential therapeutic targets for Parkinsonian cognitive disorders

12 May 2025

Abstract excerpt

BACKGROUND: Parkinson's disease (PD), the second most common neurodegenerative disease with notable clinical heterogeneity, has Parkinson disease dementia (PDD) that severely impacts patients' quality of life. As no effective treatment exists, this study aimed to find potential drug targets for PD cognitive disorders. METHODS: Two-sample Mendelian randomization (MR) and transcriptome analysis were used to...

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PMID: 40355913
DOI: 10.1186/s12967-025-06541-z

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