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Deciphering intratumor heterogeneity in clear cell renal cell carcinoma utilizing clinicopathologic and molecular platforms.

Human pathology - 1 Dec 2022

Vormittag-Nocito Erica, Mannan Rahul, Wang Xiaoming, Chinnaiyan Anya, Zhang Yuping, Zelenka-Wang Sylvia, Cao Xuhong, Morgan Todd M, Hafez Khaled, Vaishampayan Ulka, Abdulfatah Eman, Chinnaiyan Arul M, Dhanasekaran Saravana M, Mehra Rohit

Abstract excerpt

Clear cell renal cell carcinoma (CCRCC) is a common renal malignancy known for its lethality and chromosome 3p aberrancies associated with loss of VHL. It has been shown that additional prognostic molecular markers exist in other transcriptional modifiers such as BAP1 and SETD2. Molecular heterogeneity has been described between primary and metastatic sites as well as genetic diversity in spatial tumor analysis;...

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PMID: 36511267
DOI: 10.1016/j.humpath.2022.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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