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Article

Recognizing the Continuous Nature of Expression Heterogeneity and Clinical Outcomes in Clear Cell Renal Cell Carcinoma.

Scientific reports - 4 Aug 2017

Wei Xiaona, Choudhury Yukti, Lim Weng Khong, Anema John, Kahnoski Richard J, Lane Brian, Ludlow John, Takahashi Masayuki, Kanayama Hiro-Omi, Belldegrun Arie, Kim Hyung L, Rogers Craig, Nicol David, Teh Bin Tean, Tan Min-Han

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) has been previously classified into putative discrete prognostic subtypes by gene expression profiling. To investigate the robustness of these proposed subtype classifications, we evaluated 12 public datasets, together with a new dataset of 265 ccRCC gene expression profiles. Consensus clustering showed unstable subtype and principal component analysis (PCA) showed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28779136
DOI: 10.1038/s41598-017-07191-y
PMCID: PMC5544702

Genes

BAP1
MTOR
PBRM1
PTEN
SETD2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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