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Diagnostic and Prognostic Biomarkers in Renal Clear Cell Carcinoma

17 Nov 2022

Abstract excerpt

Renal clear cell carcinoma (ccRCC) comprises over 75% of all renal tumors and arises in the epithelial cells of the proximal convoluted tubule. Molecularly ccRCC is characterized by copy number alterations (CNAs) such as the loss of chromosome 3p and VHL inactivation. Additional driver mutations (SETD2, PBRM1, BAP1, and others) promote genomic instability and tumor cell metastasis through the dysregulation of...

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PMID: 36428521
DOI: 10.3390/biomedicines10112953

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