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Morphological characteristics of SETD2-mutated locally advanced clear cell renal cell carcinoma: Comparison with BAP1-mutated clear cell renal cell carcinoma.

Annals of diagnostic pathology - 1 Feb 2024

Takeda Kotaro, Bastacky Sheldon, Dhir Rajiv, Mohebnasab Maedeh, Quiroga-Garza Gabriela M

Abstract excerpt

SET-domain containing 2 (SETD2) and BRCA1-associated protein 1 (BAP1), both chromatin remodeling genes, are frequently mutated in clear cell renal cell carcinoma (ccRCC) and involved in tumor progression and metastasis. Herein, we studied clinicopathologic features of 7 cases of locally advanced ccRCC with single SETD2 mutation, and compared to 7 cases of locally advanced ccRCC with single BAP1 mutation....

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PMID: 37976977
DOI: 10.1016/j.anndiagpath.2023.152223

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