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Article

Distinct spatial landscapes in clear-cell renal cell carcinoma as revealed by whole transcriptome analysis

22 Nov 2023

Abstract excerpt

Background: Clear-cell renal cell carcinoma (ccRCC) is the most common and aggressive form of renal cancer and a paradigm of inter- and intratumor heterogeneity. We carried out an exploratory digital spatial profiling of the tumor interior and periphery of two ccRCC tumor specimens and mapped spatially the molecular and cellular composition of their tumor microenvironment and ecosystem. Materials and methods:...

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PMID: 38292905
DOI: 10.1016/j.iotech.2023.100690

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