Article
Ontological analyses reveal clinically-significant clear cell renal cell carcinoma subtypes with convergent evolutionary trajectories into an aggressive type.
EBioMedicine - 1 Jan 2020
Cai Qi, Christie Alana, Rajaram Satwik, Zhou Qinbo, Araj Ellen, Chintalapati Suneetha, Cadeddu Jeffrey, Margulis Vitaly, Pedrosa Ivan, Rakheja Dinesh, McKay Renee M, Brugarolas James, Kapur Payal
Abstract excerpt
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a particularly challenging tumor type because of its extensive phenotypic variability as well as intra-tumoral heterogeneity (ITH). Clinically, this complexity has been reduced to a handful of pathological variables such as stage, grade and necrosis, but these variables fail to capture the breadth of the disease. How different phenotypes affect patient...
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