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Clinical, pathologic, and molecular profiles of sarcomatoid and rhabdoid differentiated clear cell renal cell carcinoma: A series of 21 tumors.

Human pathology - 1 Jun 2026

Yu Yue, Wang Yingjing, Cheng Xiao, Chen Xuan, Zhao Wei, Wang Suying, Zhang Huizhi

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) with sarcomatoid and/or rhabdoid differentiation-distinct dedifferentiation phenotypes-exhibits high aggressiveness and poor prognosis. Despite recent advances, their clinicopathologic and molecular characteristics remain incompletely defined. This study analyzed 21 such cases, predominantly in males (19 patients), with a median age of 64 years (range: 29 - 83 years) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41785935
DOI: 10.1016/j.humpath.2026.106099

Genes

MTOR
TP53
BAP1
PBRM1
SETD2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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