Article
Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2015
Di Natale Concetta, Scognamiglio Pasqualina Liana, Cascella Roberta, Cecchi Cristina, Russo Anna, Leone Marilisa, Penco Amanda, Relini Annalisa, Federici Luca, Di Matteo Adele, Chiti Fabrizio, Vitagliano Luigi, Marasco Daniela
Abstract excerpt
Nucleophosmin (NPM)-1 is a multifunctional protein involved in a variety of biologic processes and has been implicated in the pathogenesis of several human malignancies. To gain insight into the role of isolated fragments in NPM1 activities, we dissected the C-terminal domain (CTD) into its helical fragments. In this study, we observed the unexpected structural behavior of the peptide fragment corresponding to...
Topics
- Amyloid
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Nucleophosmin
- Protein Aggregation, Pathological
- Protein Structure, Secondary
- Protein Structure, Tertiary