Article

P53 TAD2 Domain (38-61) Forms Amyloid-like Aggregates in Isolation

2021-04-10

Abstract excerpt

In many cases, when cellular machinery is unable to restore changed protein conformations, they start sticking through exposed hydrophobic patches and form aggregates. A strong association between protein aggregation and Human diseases (such as Alzheimer’s, Parkinson’s, and Huntington’s disease) is well proven. p53 is a transcription factor that is also known as the guardian of the genome associated with cellular...

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Literature Corpus work: 4edcfc55-fc8c-5291-bb5a-934dd06df80c
DOI: 10.1101/2021.04.09.439126

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