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Article

Aggregation of the neuroblastoma-associated mutant (S120G) of the human nucleoside diphosphate kinase-A/NM23-H1 into amyloid fibrils.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Oct 2011

Georgescauld Florian, Sabaté Raimon, Espargaró Alba, Ventura Salvador, Chaignepain Stéphane, Lacombe Marie-Lise, Lascu Ioan

Abstract excerpt

The human nucleoside diphosphate (NDP) kinase A, product of the NME1 gene also named NM23-H1, is known as a metastasis suppressor protein. A naturally occurring variant, S120G, identified in neuroblastomas, possesses native three-dimensional structure and enzymatic activity but displays reduced conformational stability and a folding defect with the accumulation of a "molten globule" folding intermediate during...

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Source

Identifiers

PMID: 21484438
DOI: 10.1007/s00210-011-0628-8

Genes

NDP
NME1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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