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Article

Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions.

Science advances - 9 Dec 2022

Christie Shaun M, Tada Takuya, Yin Yandong, Bhardwaj Amit, Landau Nathaniel R, Rothenberg Eli

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a global health crisis after its emergence in 2019. Replication of the virus is initiated by binding of the viral spike (S) protein to human angiotensin-converting enzyme 2 (ACE2) on the target cell surface. Mutations acquired by SARS-CoV-2 S variants likely influence virus-target cell interaction. Here, using single-virus tracking to capture...

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Source

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Identifiers

PMID: 36490345
DOI: 10.1126/sciadv.abo3977
PMCID: PMC9733935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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