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Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern.

Comptes rendus biologies - 21 Jun 2021

Rey Félix

Abstract excerpt

This review covers the main features of the severe acquired respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, its interaction with the main entry receptor, the human angiotensin converting enzyme 2 (ACE2), and the subsequent membrane fusion step. The focus is on the structural organization of these proteins and mechanistic aspects of their interactions that lead to cytoplasmic release of the viral...

Topics

COVID-19
Humans
Mutation
Protein Binding
SARS-CoV-2
Spike Glycoprotein, Coronavirus

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34213849
DOI: 10.5802/crbiol.53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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