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Spike Glycoprotein-Mediated Entry of SARS Coronaviruses

11 Nov 2020

Abstract excerpt

Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses and causes of epidemic diseases that have resulted in public health emergencies worldwide. Angiotensin-converting enzyme 2 (ACE2) is the receptor that allows the entry of these two viruses into host cells, a key step in the life cycle of the pathogens. The characterization of the...

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PMID: 33187074
DOI: 10.3390/v12111289

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