Article

Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entry

2020-06-15

Abstract excerpt

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the angiotensin-converting enzyme-2 (ACE2) receptor and is cleaved by transmembrane protease serine 2 (TMPRSS2). However, whether S mutations affect SAR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a17f907-baaf-58ff-961c-5ace80623199
DOI: 10.1101/2020.06.15.151779

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entryDOI 10.1101/2020.06.15.151779Read

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity.Semantic proximity Read

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization.Semantic proximity Read

Functional importance of the D614G mutation in the SARS-CoV-2 spike protein.Semantic proximity Read

D614G mutation of SARS-CoV-2 spike protein enhances viral infectivitySemantic proximity Read

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity.Semantic proximity Read

SARS-CoV-2 spike D614G change enhances replication and transmission.Semantic proximity Read

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell typesSemantic proximity Read

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and NeutralizationSemantic proximity Read

Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions.Semantic proximity Read

SARS-CoV-2: phylogenetic status, mutations and therapeutic research based on spike protein.Semantic proximity Read

The spike glycoprotein of SARS-CoV-2: A review of how mutations of spike glycoproteins have driven the emergence of variants with high transmissibility and immune escape.Semantic proximity Read

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibilitySemantic proximity Read