Article
Computationally-guided design and selection of high performing ribosomal active site mutants.
Nucleic acids research - 9 Dec 2022
Kofman Camila, Watkins Andrew M, Kim Do Soon, Willi Jessica A, Wooldredge Alexandra C, Karim Ashty S, Das Rhiju, Jewett Michael C
Abstract excerpt
Understanding how modifications to the ribosome affect function has implications for studying ribosome biogenesis, building minimal cells, and repurposing ribosomes for synthetic biology. However, efforts to design sequence-modified ribosomes have been limited because point mutations in the ribosomal RNA (rRNA), especially in the catalytic active site (peptidyl transferase center; PTC), are often functionally...
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