Article
Community science designed ribosomes with beneficial phenotypes.
Nature communications - 21 Feb 2023
Krüger Antje, Watkins Andrew M, Wellington-Oguri Roger, Romano Jonathan, Kofman Camila, DeFoe Alysse, Kim Yejun, Anderson-Lee Jeff, Fisker Eli, Townley Jill, d'Aquino Anne E, Das Rhiju, Jewett Michael C
Abstract excerpt
Functional design of ribosomes with mutant ribosomal RNA (rRNA) can expand opportunities for understanding molecular translation, building cells from the bottom-up, and engineering ribosomes with altered capabilities. However, such efforts are hampered by cell viability constraints, an enormous combinatorial sequence space, and limitations on large-scale, 3D design of RNA structures and functions. To address...
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