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Article

Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs.

Molecular cell - 20 May 2021

Shiver Anthony L, Osadnik Hendrik, Peters Jason M, Mooney Rachel A, Wu Peter I, Henry Kemardo K, Braberg Hannes, Krogan Nevan J, Hu James C, Landick Robert, Huang Kerwyn Casey, Gross Carol A

Abstract excerpt

The multi-subunit bacterial RNA polymerase (RNAP) and its associated regulators carry out transcription and integrate myriad regulatory signals. Numerous studies have interrogated RNAP mechanism, and RNAP mutations drive Escherichia coli adaptation to many health- and industry-relevant environments, yet a paucity of systematic analyses hampers our understanding of the fitness trade-offs from altering RNAP...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34019789
DOI: 10.1016/j.molcel.2021.04.027
PMCID: PMC8484514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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