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Article

rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.

Nucleic acids research - 1 Mar 2008

Rakauskaite Rasa, Dinman Jonathan D

Abstract excerpt

To ensure accurate and rapid protein synthesis, nearby and distantly located functional regions of the ribosome must dynamically communicate and coordinate with one another through a series of information exchange networks. The ribosome is approximately 2/3 rRNA and information should pass mostly through this medium. Here, two viable mutants located in the peptidyltransferase center (PTC) of yeast ribosomes were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18203742
DOI: 10.1093/nar/gkm1179
PMCID: PMC2275155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.PMID 18203742Read ↗

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