Potential new antibiotic sites in the ribosome revealed by deleterious mutations in RNA of the large ribosomal subunit.

Abstract excerpt

The ribosome is the main target for antibiotics that inhibit protein biosynthesis. Despite the chemical diversity of the known antibiotics that affect functions of the large ribosomal subunit, these drugs act on only a few sites corresponding to some of the known functional centers. We have used a genetic approach for identifying structurally and functionally critical sites in the ribosome that can be used as new...

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