Article
Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer's disease.
Oncotarget - 13 Sept 2016
Chen Jiu, Shu Hao, Wang Zan, Liu Duan, Shi Yongmei, Xu Lin, Zhang Zhijun
Abstract excerpt
The apolipoprotein E (APOE) ε4 allele associates with accelerating the conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD), whereas the protectiveAPOEε2 allele appears to be against the disease. Moreover, entorhinal cortex (ERC) is one of the earliest brain regions of AD pathology that disrupts the formation of episodic memory. To investigate the effects of APOE ε2 and ε4alleles...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.