Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation.

Cerebral cortex (New York, N.Y. : 1991) - 10 Mar 2023

Cacciaglia Raffaele, Operto Grégory, Falcón Carles, de Echavarri-Gómez José Maria González, Sánchez-Benavides Gonzalo, Brugulat-Serrat Anna, Milà-Alomà Marta, Blennow Kaj, Zetterberg Henrik, Molinuevo José Luis, Suárez-Calvet Marc, Gispert Juan Domingo

Abstract excerpt

The investigation of resting-state functional connectivity (rsFC) in asymptomatic individuals at genetic risk for Alzheimer's disease (AD) enables discovering the earliest brain alterations in preclinical stages of the disease. The APOE-ε4 variant is the major genetic risk factor for AD, and previous studies have reported rsFC abnormalities in carriers of the ε4 allele. Yet, no study has assessed APOE-ε4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Mapping

Share to Cognition

Share to Magnetic Resonance Imaging

Share to Nerve Net

Share to Neural Pathways

Source

Open in PubMed Open full text

Identifiers

PMID: 35753703
DOI: 10.1093/cercor/bhac239
PMCID: PMC10016049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation.PMID 35753703Read ↗

APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks.Semantic proximity Read ↗

The effects of APOE on the functional architecture of the resting brain.Semantic proximity Read ↗

APOE ε 4 and resting‐state functional connectivity in racially/ethnically diverse older adultsSemantic proximity Read ↗

Recognition memory is associated with altered resting-state functional connectivity in people at genetic risk for Alzheimer's disease.Semantic proximity Read ↗

Influence of the APOE ε4 allele and mild cognitive impairment diagnosis in the disruption of the MEG resting state functional connectivity in sources space.Semantic proximity Read ↗

The effects of APOEe4 allele on cerebral structure, function, and related interactions with cognition in young adults.Semantic proximity Read ↗

APOE Polymorphism Affects Brain Default Mode Network in Healthy Young AdultsSemantic proximity Read ↗

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individualsSemantic proximity Read ↗

Exploring the Interaction of APOE- <i>ε</i> 4 and PICALM rs3851179 With Dynamic Functional Connectivity in Healthy Middle-Aged Adults at Risk for Alzheimer’s DiseaseSemantic proximity Read ↗

Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer's disease.Semantic proximity Read ↗

Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study.Semantic proximity Read ↗

The apolipoprotein E gene affects the three-year trajectories of compensatory neural processes in the left-lateralized hippocampal network.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.