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Article

3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosine

30 Nov 2022

Abstract excerpt

BACKGROUND: Miltefosine treatment failure in visceral leishmaniasis in Brazil has been associated with deletion of the miltefosine susceptibility locus (MSL) in Leishmania infantum. The MSL comprises four genes, 3'-nucleotidase/nucleases (NUC1 and NUC2); helicase-like protein (HLP); and 3,2-trans-enoyl-CoA isomerase (TEI). METHODS: In this study CRISPR-Cas9 was used to either epitope tag or delete NUC1, NUC2, HLP...

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PMID: 36462405
DOI: 10.1016/j.ebiom.2022.104378

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