Genomewide Analysis of Mode of Action of the S -Adenosylmethionine Analogue Sinefungin in Leishmania infantum

Abstract excerpt

The two main cellular metabolic one-carbon donors are reduced folates and S -adenosylmethionine, whose biosynthetic pathways have proven highly effective in chemotherapeutic interventions in various cell types. Sinefungin, a nucleoside analogue of S -adenosylmethionine, was shown to have potent activity against the protozoan parasite Leishmania . Here, we studied resistance to sinefungin using whole-genome...

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