Article

p1/s1, a 3’-nucleotidase/nuclease, allows <i>Leishmania major</i> to circumvent host innate immune response mechanisms

2025-08-19

Abstract excerpt

3’-nucleotidases/nucleases, distinct class I nucleases of protozoan parasites, play a pivotal role in extracellular purine salvage. As Leishmania are purine auxotrophs and lack de novo synthesis, ectoenzymes facilitating nucleotide and nucleic acid cleavage are indispensable for subsequent uptake. Employing quantitative proteomics, we identified a class I nuclease p1/s1 cluster in L. major that comprises enzym...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 300d849e-5067-5f13-bcb4-7a8f9cd99348
DOI: 10.1101/2025.08.15.670482

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

p1/s1, a 3’-nucleotidase/nuclease, allows <i>Leishmania major</i> to circumvent host innate immune response mechanismsDOI 10.1101/2025.08.15.670482Read

Gene deletion as a possible strategy adopted by New World <i>Leishmania infantum</i> to maximize geographic dispersionSemantic proximity Read

Leishmania guyanensis controls endogenous viral replication by a canonical RNA interference pathwaySemantic proximity Read

A novel <i>Leishmania infantum</i> reference strain for gene editing and the study of visceral leishmaniasisSemantic proximity Read

A short noncoding RNA modulates gene expression and affects stress response and parasite differentiation in <i>Leishmania braziliensis</i>Semantic proximity Read

3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosineSemantic proximity Read

TransLeish: Identification of membrane transporters essential for survival of intracellular <i>Leishmania</i> parasites in a systematic gene deletion screenSemantic proximity Read

Comparative and systems analyses of <i>Leishmania</i> spp. non-coding RNAs through developmental stagesSemantic proximity Read

Recent advances in Leishmania reverse genetics: Manipulating a manipulative parasiteSemantic proximity Read

<i>Leishmania</i> infection triggers hepcidin-mediated proteasomal degradation of Nramp1 resulting in increased phagolysosomal iron availabilitySemantic proximity Read

CRISPR/Cas9-mediated identification of human macrophage SphK1 as druggable target for development of anti-leishmanial chemotherapeuticsSemantic proximity Read

Essential gene identification and drug target prioritization in <i>Leishmania</i> speciesSemantic proximity Read

Leishmaniasis: Omics Approaches to Understand its Biology from Molecule to Cell LevelSemantic proximity Read