Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

doi:10.1371/journal.pone.0154101

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Article

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

PloS one - 1 Jan 2016

Mondelaers Annelies, Sanchez-Cañete Maria P, Hendrickx Sarah, Eberhardt Eline, Garcia-Hernandez Raquel, Lachaud Laurence, Cotton James, Sanders Mandy, Cuypers Bart, Imamura Hideo, Dujardin Jean-Claude, Delputte Peter, Cos Paul, Caljon Guy, Gamarro Francisco, Castanys Santiago, Maes Louis

Abstract excerpt

During the last decade miltefosine (MIL) has been used as first-line treatment for visceral leishmaniasis in endemic areas with antimonial resistance, but a decline in clinical effectiveness is now being reported. While only two MIL-resistant Leishmania infantum strains from HIV co-infected patients have been documented, phenotypic MIL-resistance for L. donovani has not yet been identified in the laboratory....

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PMID: 27123924
DOI: 10.1371/journal.pone.0154101
PMCID: PMC4849676

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