Article

Gene deletion as a possible strategy adopted by New World <i>Leishmania infantum</i> to maximize geographic dispersion

2024-05-22

Abstract excerpt

<h4>Background</h4> The present study investigates implications of a sub-chromosomal deletion in Leishmania infantum strains, the causative agent of American Visceral Leishmaniasis (AVL). Primarily found in New World strains, the deletion leads to the absence of the ecto-3’-nucleotidase/nuclease enzyme (3’NU/NT), impacting parasite virulence, pathogenicity, and drug susceptibility. The potential factors favoring...

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Literature Corpus work: cbfb5116-775f-512b-90b8-fba90be31337
DOI: 10.1101/2024.05.22.595165

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