Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine

15 Feb 2018

Abstract excerpt

ABSTRACT With the World Health Organization reporting over 30,000 deaths and 200,000 to 400,000 new cases annually, visceral leishmaniasis is a serious disease affecting some of the world's poorest people. As drug resistance continues to rise, there is a huge unmet need to improve treatment. Miltefosine remains one of the main treatments for leishmaniasis, yet its mode of action (MoA) is still unknown....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Research on Leishmaniasis Studies
Share to Toxin Mechanisms and Immunotoxins
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29463533
DOI: 10.1128/aac.02095-17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by MiltefosinePMID 29463533Read ↗

In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization.Semantic proximity Read ↗

Metabolomics to unveil and understand phenotypic diversity between pathogen populations.Semantic proximity Read ↗

Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic ApproachSemantic proximity Read ↗

Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug CandidatesSemantic proximity Read ↗

Metabolomic-Based Strategies for Anti-Parasite Drug DiscoverySemantic proximity Read ↗

Molecular Mechanisms of Drug Resistance in Leishmania spp.Semantic proximity Read ↗

CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azolesSemantic proximity Read ↗

3′Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosineSemantic proximity Read ↗

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.Semantic proximity Read ↗

Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.Semantic proximity Read ↗

Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasitesSemantic proximity Read ↗

Omics Approaches in Drug Development against Leishmaniasis: Current Scenario and Future ProspectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.