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Article

In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization.

Molecular microbiology - 1 Mar 2016

Shaw C D, Lonchamp J, Downing T, Imamura H, Freeman T M, Cotton J A, Sanders M, Blackburn G, Dujardin J C, Rijal S, Khanal B, Illingworth C J R, Coombs G H, Carter K C

Abstract excerpt

In this study, we followed the genomic, lipidomic and metabolomic changes associated with the selection of miltefosine (MIL) resistance in two clinically derived Leishmania donovani strains with different inherent resistance to antimonial drugs (antimony sensitive strain Sb-S; and antimony resistant Sb-R). MIL-R was easily induced in both strains using the promastigote-stage, but a significant increase in MIL-R...

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Identifiers

PMID: 26713880
DOI: 10.1111/mmi.13291
PMCID: PMC4832254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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