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Article

Downregulation of FeSOD-A expression in Leishmania infantum alters trivalent antimony and miltefosine susceptibility.

Parasites & vectors - 15 Jul 2021

Santi Ana Maria Murta, Silva Paula Alves, Santos Isabella Fernandes Martins, Murta Silvane Maria Fonseca

Abstract excerpt

BACKGROUND: Superoxide dismutase (SOD), a central component of the antioxidant defence system of most organisms, removes excess superoxide anions by converting them to oxygen and hydrogen peroxide. As iron (Fe) SOD is absent in the human host, this enzyme is a promising molecular target for drug development against trypanosomatids. RESULTS: We obtained Leishmania infantum mutant clones with lower FeSOD-A...

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Identifiers

PMID: 34266485
DOI: 10.1186/s13071-021-04838-8
PMCID: PMC8281622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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