Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity.

doi:10.1158/0008-5472.CAN-22-3050

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Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity.

Cancer research - 3 Feb 2023

Williams Hannah L, Dias Costa Andressa, Zhang Jinming, Raghavan Srivatsan, Winter Peter S, Kapner Kevin S, Ginebaugh Scott P, Väyrynen Sara A, Väyrynen Juha P, Yuan Chen, Navia Andrew W, Wang Junning, Yang Annan, Bosse Timothy L, Kalekar Radha L, Lowder Kristen E, Lau Mai Chan, Elganainy Dalia, Morales-Oyarvide Vicente, Rubinson Douglas A, Singh Harshabad, Perez Kimberly, Cleary James M, Clancy Thomas E, Wang Jiping, Mancias Joseph D, Brais Lauren K, Hill Emma R, Kozak Margaret M, Linehan David C, Dunne Richard F, Chang Daniel T, Koong Albert C, Hezel Aram F, Hahn William C, Shalek Alex K, Aguirre Andrew J, Nowak Jonathan A, Wolpin Brian M

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has been classified into classical and basal-like transcriptional subtypes by bulk RNA measurements. However, recent work has uncovered greater complexity to transcriptional subtypes than was initially appreciated using bulk RNA expression profiling. To provide a deeper understanding of PDAC subtypes, we developed a multiplex immunofluorescence (mIF) pipeline that...

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Identifiers

PMID: 36459568
DOI: 10.1158/0008-5472.CAN-22-3050
PMCID: PMC10548885

Genes

CLDN18
GATA6
KRT17
KRT5
S100A2
TFF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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