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Article

Co-occurring KEAP1 and TP53 mutations in lung squamous cell carcinoma induced primary resistance to thoracic radiotherapy: A case report.

Thoracic cancer - 1 Jan 2023

Nishimura Rumi, Yoshida Tatsuya, Torasawa Masahiro, Kashihara Tairo, Ohe Yuichiro

Abstract excerpt

In lung squamous cell carcinoma, KEAP1 mutations frequently coexist with TP53 mutations. A preclinical model showed that mutations leading to the activation of the KEAP1-NRF2 pathway contribute to clinical radioresistance. However, there have been few clinical reports on the association between the presence of KEAP1 and TP53 mutations in patients with lung squamous cell carcinoma. Here, we report the case of a...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kelch-Like ECH-Associated Protein 1

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Source

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Identifiers

PMID: 36453575
DOI: 10.1111/1759-7714.14751
PMCID: PMC9834690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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