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Article

Comprehensive Analysis of TP53 and KEAP1 Mutations and Their Impact on Survival in Localized- and Advanced-Stage NSCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2022

Saleh Mohamed Mahde, Scheffler Matthias, Merkelbach-Bruse Sabine, Scheel Andreas Hans, Ulmer Bastian, Wolf Jürgen, Buettner Reinhard

Abstract excerpt

INTRODUCTION: TP53 and KEAP1 are frequently mutated in NSCLC, but their prognostic value is ambiguous, particularly in localized stage tumors. METHODS: This retrospective cohort study included a total of 6297 patients with NSCLC who were diagnosed between November 1998 and February 2020. The primary end point was overall survival. Patients were diagnosed in a central pathology laboratory as part of the Network...

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PMID: 34601169
DOI: 10.1016/j.jtho.2021.08.764

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