Article
Dynamic Mutational Landscape of Cerebrospinal Fluid Circulating Tumor DNA and Predictors of Survival after Proton Craniospinal Irradiation for Leptomeningeal Metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research - 16 Feb 2023
Wijetunga N Ari, Goglia Alexander G, Weinhold Nils, Berger Michael F, Cislo Michael, Higginson Daniel S, Chabot Kiana, Osman Ahmed M, Schaff Lauren, Pentsova Elena, Miller Alexandra M, Powell Simon N, Boire Adrienne, Yang Jonathan T
Abstract excerpt
PURPOSE: Proton craniospinal irradiation (pCSI) is a promising treatment for patients with solid tumor leptomeningeal metastasis (LM). We hypothesize that genetic characteristics before and changes resulting after pCSI will reflect clinical response to pCSI. We analyzed the cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) from patients receiving pCSI for LM and explored genetic variations associated with...
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