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Article

Cerebrospinal fluid circulating tumor DNA contributes to the detection and characterization of leptomeningeal metastasis in non-small cell lung cancer.

Journal of neuro-oncology - 1 Dec 2023

Miao Qian, Zheng Xinlong, Li Lifeng, Zheng Xiaobin, Zhang Longfeng, Jiang Kan, Wu Shiwen, Wang Haibo, Wu Biao, Xu Yiquan, Zhong Qiaofeng, Zou Zihua, Zhang Qiuyu, Yang Shanshan, Li Yujing, Lin Gen

Abstract excerpt

PURPOSE: Cerebrospinal fluid (CSF) has revealed the unique genetic characteristics of leptomeningeal metastasis (LM) from non-small cell lung cancer (NSCLC). However, the research in this area is still very limited. METHODS: Patients with LM from NSCLC (n = 80) were retrospectively analyzed. Circulating tumor DNA (ctDNA) in CSF was tested by next-generation sequencing (NGS), with paired extracranial tissue or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38104049
DOI: 10.1007/s11060-023-04520-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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