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Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

12 Oct 2021

Abstract excerpt

Leptomeningeal disease (LMD) is a devastating complication of solid tumor malignancies, with dire prognosis and no effective systemic treatment options. Over the past decade, the incidence of LMD has steadily increased due to therapeutics that have extended the survival of cancer patients, highlighting the need for new interventions. To examine the efficacy of immune checkpoint inhibitors (ICI) in patients with...

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PMID: 34642316
DOI: 10.1038/s41467-021-25860-5

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