Article
Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028).
BMC medicine - 14 Nov 2022
Li Meichen, Chen Jing, Zhang Baishen, Yu Juan, Wang Na, Li Delan, Shao Yang, Zhu Dongqin, Liang Chuqiao, Ma Yutong, Ou Qiuxiang, Hou Xue, Chen Likun
Abstract excerpt
BACKGROUND: Due to the blood-brain barrier, plasma is not an ideal source to evaluate the genetic characteristics of central nervous system tumors. Thus, cerebrospinal fluid (CSF) is becoming an alternative biopsy type to evaluate the genetic landscape of intracranial tumors. We aimed to explore the genetic profiles of CSF-derived circulating tumor DNA (ctDNA) to predict intracranial tumor responses and monitor...
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