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Article

Brain tumor mutations detected in cerebral spinal fluid.

Clinical chemistry - 1 Mar 2015

Pan Wenying, Gu Wei, Nagpal Seema, Gephart Melanie Hayden, Quake Stephen R

Abstract excerpt

BACKGROUND: Detecting tumor-derived cell-free DNA (cfDNA) in the blood of brain tumor patients is challenging, presumably owing to the blood-brain barrier. Cerebral spinal fluid (CSF) may serve as an alternative "liquid biopsy" of brain tumors by enabling measurement of circulating DNA within CSF to characterize tumor-specific mutations. Many aspects about the characteristics and detectability of tumor mutations...

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Identifiers

PMID: 25605683
DOI: 10.1373/clinchem.2014.235457
PMCID: PMC5412506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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