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Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

10 Nov 2015

Abstract excerpt

Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the genomic alterations present in tumours and has been used to monitor tumour progression and response to treatments. However, patients with brain tumours do not present with or present with low amounts of ctDNA in plasma precluding the genomic characterization of brain cancer through plasma ctDNA. Here we show that ctDNA...

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PMID: 26554728
DOI: 10.1038/ncomms9839

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