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Article

Cerebrospinal fluid circulating tumour DNA genotyping and survival analysis in lung adenocarcinoma with leptomeningeal metastases.

Journal of neuro-oncology - 1 Oct 2023

Bai Kaixuan, Chen Xin, Qi Xuejiao, Zhang Yu, Zou Yueli, Li Jian, Yu Lili, Li Yuanyuan, Jiang Jiajia, Yang Yi, Liu Yajing, Feng Shuanghao, Bu Hui

Abstract excerpt

PURPOSE: The prognosis of patients with leptomeningeal metastasis (LM) remains poor. Circulating tumour DNA (ctDNA) has been proven to be abundantly present in cerebrospinal fluid (CSF); hence, its clinical implication as a biomarker needs to be further verified. METHODS: We conducted a retrospective study of 35 lung adenocarcinoma (LUAD) patients with LM, and matched CSF and plasma samples were collected from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37897649
DOI: 10.1007/s11060-023-04471-8
PMCID: PMC10638181

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