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Article

Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Evgen'ev Michail B, Krasnov George S, Nesterova Inna V, Garbuz David G, Karpov Vadim L, Morozov Alexey V, Snezhkina Anastasiya V, Samokhin Alexander N, Sergeev Alexander, Kulikov Alexei M, Bobkova Natalia V

Abstract excerpt

Heat shock protein 70, encoded by the HSPA1A gene in humans, is a key component of the machinery that protects neuronal cells from various stress conditions and whose production significantly declines during the course of aging and as a result of several neurodegenerative diseases. Herein, we investigated whether sub-chronic intranasal administration of exogenous Hsp70 (eHsp70) exerts a neuroprotective effect on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28759972
DOI: 10.3233/JAD-170398

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