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Article

Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain.

International journal of molecular sciences - 13 Jan 2022

Rodriguez Ospina Santiago, Blazier Danielle M, Criado-Marrero Marangelie, Gould Lauren A, Gebru Niat T, Beaulieu-Abdelahad David, Wang Xinming, Remily-Wood Elizabeth, Chaput Dale, Stevens Stanley, Uversky Vladimir N, Bickford Paula C, Dickey Chad A, Blair Laura J

Abstract excerpt

The microtubule-associated protein tau pathologically accumulates and aggregates in Alzheimer's disease (AD) and other tauopathies, leading to cognitive dysfunction and neuronal loss. Molecular chaperones, like small heat-shock proteins (sHsps), can help deter the accumulation of misfolded proteins, such as tau. Here, we tested the hypothesis that the overexpression of wild-type Hsp22 (wtHsp22) and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35055033
DOI: 10.3390/ijms23020851
PMCID: PMC8775832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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